Study on Simultaneous Determination of Three Nitroimidazole Residues in Honey by Resonance Rayleigh Scattering Spectra (CAT#: STEM-ST-0042-YJL)

Introduction

Metronidazole (MNZ), Ornidazole (ONZ), and Tinidazole (TNZ) are all nitroimidazole drugs, which is able to defend against the diseases such as amoebiasis, trichomoniasis, and anaerobic infections. MNZ is a nitroimidazole antibiotic that causes bacterial death when it is reduced in humans with effects on inhibiting bacterial DNA synthesis. TNZ was first developed in the United States, it is a new generation of nitroimidazole drugs after MNZ with higher efficacy, shorter duration of treatment, better tolerability. ONZ is the third-generation nitroimidazole drug widely used after MNZ and TNZ.
In recent years, some commonly used drugs such as chloramphenicol and MNZ have been strictly banned in agricultural production, Beekeepers have gradually used ONZ and TNZ as alternative drugs to control “Climbing bee disease”. However, the nitroimidazole drugs have mutagenic, teratogenic and suspicious carcinogenic effects, so it is particularly important to investigate the quantitative determination methods of the three nitroimidazole drugs.