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Protein acetylation (Acetylation) is a process in which a protein is catalyzed by an acetyltransferase (or non-enzyme), and the acetyl group is transferred and added to a protein lysine residue or a protein N-terminal. important role in protein structure and gene expression. Acetylation modification is mainly divided into two categories: acetylation modification at the N-terminal of protein and acetylation modification on protein lysine. Most of the N-terminal acetylation modification occurs on eukaryotic proteins, catalyzed by N acetyltransferases (NATs); acetylation modification on lysine is a reversible process, mainly catalyzed by lysine acetylases (KATs ) and lysine deacetylases (KDACs).