Alzheimer's Animal Model (CAT#: STEM-AE-0029-WXH)

Introduction

Dementia generally refers to Alzheimer's disease. Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown.

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Principle Applications Procedure Materials Notes Related Products

Applications

• Research on the pathogenesis and treatment of Alzheimer's disease.
• Drug development, drug screening and efficacy research.

Procedure

• Dementia model induced by cholinergic damage: cut off the fornix-fimbria hippocampus after anesthetizing rats/inject chemical drugs.
• Aβ injection-induced dementia model: inject Aβ into bilateral hippocampus.
• Vascular dementia (VD) animal model: bilateral carotid artery occlusion.

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