Animal Model of Embolism Cerebral Infarction (CAT#: STEM-AE-0033-WXH)

Introduction

Cerebral infarction, also known as ischemic stroke, is called stroke or stroke in traditional Chinese medicine. The disease is caused by a variety of causes of blood supply disturbance in the local brain tissue, leading to ischemic and hypoxic lesions and necrosis of the brain tissue, resulting in clinically corresponding neurological deficits. According to different pathogenesis, cerebral infarction is divided into main types such as cerebral thrombosis, cerebral embolism and lacunar infarction. Among them, cerebral thrombosis is the most common type of cerebral infarction, accounting for about 60% of all cerebral infarctions, so the commonly referred to as "cerebral infarction" actually refers to cerebral thrombosis.

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Principle Applications Procedure Materials Notes Related Products

Applications

• Study the pathogenesis and pathophysiological process of cerebral infarction.
• Study thrombolytic therapy, route of administration, drug efficacy and safety.

Procedure

• Modeling method of venous thromboembolism (VTE) rat model
1. Fast the night before the operation and drink water freely.
2. Weigh the rat and anesthetize it.
3. Open the abdominal cavity, bluntly separate the inferior vena cava, ligate the inferior vena cava and its main branches below the renal vein, suture the inner and outer layers, and place the rat on a heating pad to maintain the rectal temperature at 37±0.5°C.
4. After the rats wake up, drink water freely and feed them normally.
• Method of injecting microemboli suspension: take blood from the heart, place it at room temperature for 48 hours to form a thrombus, use a syringe to aspirate the blood clot and inject it into normal saline, repeat 3 times to form a microemboli suspension. Aspirate the suspension into the ICA from the common carotid artery (CCA).
• Intravascular infusion of thrombin.

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