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Almost all physiological activities are regulated by Ca2+. The basis of Ca2+ as a cell messenger is that there is a concentration gradient between cytoplasmic Ca2+ and intracellular calcium store or extracellular Ca2+. When a certain stimulus greatly increases the intracellular Ca2+ concentration, it plays a role in transmitting signals. The characteristics of Ca2+ itself are more conducive to binding to the target protein, thereby transmitting information. Due to the integration of multiple functions, the Ca2+ signal must be very flexible and must be strictly controlled at the same time. It is realized by means of different intermediate links of the Ca2+ signal, that is, Ca2+ can act with different amplitudes in different time and space. Different types of cells complete their specific physiological functions with different combinations of calcium signals.