Fibroblast GF (FGF) detection service (CAT#: STEM-MB-0254-WXH)

FGF-mediated activation of the RAS-MAP kinase pathway can be observed in all cell types, while the activity of other signal transduction pathways depends on the cell type. The key component of FGF signaling is the docking protein FRS2α, which is phosphorylated by tyrosine residues after FGF stimulation. It is the core of a signaling complex composed of the tyrosine phosphatase Shp2, the adaptor Grb2, and the docking protein GAB1, which leads to the activation of the RAS-MAP kinase. The FRS2 signaling complex recruits the guanine nucleotide exchange factor SOS through the binding of Grb2, thereby activating downstream effectors of Ras and MAP kinases, and thus regulating cell transcription.

It promotes fibroblast mitosis and mesoderm cell growth. It can also stimulate blood vessel formation and play a role in wound healing and limb regeneration.
It can promote the production of a large number of osteoblasts and inhibit osteoclasts, which can be used to treat osteoporosis, femoral head necrosis, arthritis, rheumatism and diseases caused by calcium deficiency.
Strengthen gastrointestinal functions, promote the breakdown of digestive enzymes, increase appetite, and treat chronic gastritis.
Strengthen the bone marrow hematopoietic function, promote the generation of stem cells, and then generate a large number of red blood cells and white blood cells.
Strengthen left ventricular thickness, increase myocardial elasticity, and effectively treat heart disease. Effectively removes low-density proteins in the blood, prevents deposition on blood vessel walls, and treats blood clots.

1. Process samples.
2. FGF detection (Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Serum, cell supernatant, urine, body fluids, lavage fluid, cerebral spinal cord, atrial fluid, pleural fluid, tissue, etc.