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Epigenetics Pathway Assay (CAT#: STEM-MB-0327-WXH)

Introduction

Epigenetics refers to changes in gene expression levels based on non-gene sequence changes, including DNA methylation, histone modification, chromosome remodeling and non-coding RNA regulation, mainly through the process of gene transcription or translation The regulation and control of it affects its functions and characteristics.
Epigenetics is a branch of genetics that studies the heritable changes in gene expression when the nucleotide sequence of a gene does not change. There are many epigenetic phenomena, known as DNA methylation, genomic imprinting, maternal effects, gene silencing, nucleolar dominance, dormant transposons Activation and RNA editing (RNA editing), etc.

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Principle Applications Procedure Notes

Principle

Changes in epigenetic gene expression do not depend on changes in gene sequences, but on chemical modifications of DNA and histones, including acetylation, methylation, phosphorylation, ubiquitination, ADP ribosylation, etc. Modification of the transcriptional activity of genes, the current concept of epigenetics also includes the category of non-coding RNA (ncRNA). The most common epigenetic change in tumorigenesis is the methylation of CpG islands in the promoter region of tumor suppressor genes. Methylation silencing related gene expression can affect related tumor signaling pathways. Epigenetics has become a new target for individualized treatment of tumors, and many epigenetic changes can also be used as sensitivity markers for chemotherapeutics.

Applications

To study the regulation mechanism of epigenetics signal pathway in disease
To study the effect of each virus on epigenetics signaling pathway
To study the effects of drugs or therapies on epigenetics signaling pathways

Procedure

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Notes

Detectable targets: DF1, BID, IAPs, tBID, SODD, Bad, DF2, Bax, PIDD, MYD88, Rac1, TLR4, DF3, RIP1, TRAF-2, FADD, APAF-1, BID, METTL3, IRF7, Mda-5, NFκB, RIG-1, TRAF3, METTL14, IRF9, MEKK1, p38, RIP1, TRAF5, Histone-H3, IRF5, MEK3, p38MAPK, SH2, TRAF6, POL, II, IRS1, MEK6, p50, SLP76, TRAM, FTO, IRS2, MSK1, p65, Tak1, TRIF

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