ROCK Signaling Pathway Assay (CAT#: STEM-MB-0313-WXH)

Introduction

Rho-associated kinase (ROCK) is currently the most detailed functional study of Rho downstream target effect molecules. The ROCK signal pathway is a ubiquitous pathway in the central nervous system, and it is an important way to mediate inhibitory signals and block the regeneration of central nerve cells. The ROCK signaling pathway induces cytoskeletal reorganization, cell migration and stress fiber formation, and has various physiological functions such as endothelial permeability, tissue contraction and growth.

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Principle Applications Procedure Materials Notes Related Products

Principle

The ROCK signal path includes:
Inhibitory proteins: such as myelin associated glycoprotein (MAG), neuronal growth inhibitor (including Nogo-A, Nogo-B and Nogo-C) and oligodendrocytes Myelin glycoprotein (OMgp).
Receptors that can bind to the inhibitory protein: such as Nogo receptor (NgR), paired immunoglobulin-like receptor B (PirB), p75 neurotrophic receptor (p75 neurotrophic receptor, p75NTR).
Rho factor.
ROCK and ROCK effector molecules.

Applications

Study the impact of each clinical virus on the ROCK signaling pathway
Research on the regulatory mechanism of ROCK signaling pathway in medicine
Study the effects of drugs or therapies on the ROCK signaling pathway

Procedure

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Notes

Detectable targets: MSK2, SLP76, p38MAPK, MYD88, Rac1, TLR4, ATG16, WIPi2, LC3I, PROLC3, ULK, FIP200, TRIF, VPS34, UYRAG, NFκB, RIG-1, p50, Vav, IRF9, AMBRA1, p38, RIP1, TRAF5, Histone-H3, IRF5, MEK3, mTOR, SH2, TRAF6, ATG3, IRS1, MEK6, PKR, ISRE, TRAM, ISGF3, IRS2, MSK1, p65, Tak1, TBK1

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