IL-36 Detection (CAT#: STEM-MB-0302-WXH)

Introduction

Interleukin 36 (IL-36) belongs to IL-1 family and is an important mediator of inflammatory diseases. IL-36 includes IL-36α, IL-36β, IL-36γ and IL-36 receptor antagonists (IL-36Ra). IL-36Ra, IL-36α, IL-36β and IL-36γ were named as members of IL-1 family 5, 6, 8 and 9, respectively, and they all mediate signal transmission by IL-1 receptor-related protein (IL-1Rrp2) and IL- 1 receptor accessory protein (IL-1RAcP). IL-36Ra can prevent the activation of IL-36 receptor signal, so it has an inhibitory effect on the immune response of inflammatory diseases. IL-36 is involved in the occurrence and development of various inflammatory diseases, such as psoriasis, localized hair loss, joint inflammation, lung inflammation, and other inflammatory diseases.

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Principle Applications Procedure Materials Notes Related Products

Principle

IL-36 has a significant effect on dendritic cells and T cells. In mouse dendritic cells, IL-36R agonists can up-regulate CD80, CD86 and MHCⅡ, thereby inducing the production of IL-6 and IL-12, and the production of IL-6 and IL-12 mainly depends on IL-36R Signal pathway. IL-36α, IL-36β and IL-36γ activate mitogen-activated protein kinases (MAPK pathway) through IL-1Rrp2 and IL-1RAcP to produce a large number of cytokines, chemokines, adhesion molecules and enzymes and other inflammatory mediators, which in turn mediate Inflammation.

Applications

IL-36 is an important mediator of inflammatory diseases.
IL-36 has an inhibitory effect on the immune response of inflammatory diseases.
IL-36 is involved in the occurrence and development of various inflammatory diseases, such as psoriasis, localized hair loss, joint inflammation, lung inflammation, and other inflammatory diseases.

Procedure

1. Process samples.
2. IL-36 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Notes

Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.

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