CC Subfamily Detection Service (CAT#: STEM-MB-0260-WXH)

CC chemokine receptors are membrane proteins that specifically bind and respond to the CC chemokine family. They are a large family of G protein-coupled receptors that transmembrane seven times. When the released CC chemokine binds to the CC chemokine receptor on the surface of the target cell, a transmembrane transmission of the signal is initiated. Because the intracellular signal transduction of the CC chemokine receptor depends on the adjacent G protein, the receptor is in an inactive state when GDP binds to the receptor G protein. After binding to the chemokine ligand, the chemokine receptor can replace the G protein-bound GDP with a GTP molecule and dissociate the G protein subunit to complete the activation of the G protein.

CC chemokines can induce the migration of monocytes and other cell types such as NK cells and dendritic cells.
Analyze the function of chemokines, from intracellular transport to signal transduction activities.
Study the relationship between chemokines and the mechanism of occurrence and metastasis of various diseases. For example, it plays a role in the production and differentiation of immune cells and bone marrow hematopoietic cells, development regulation and immune response regulation.
Develop new anti-inflammatory drugs based on the physiological functions of chemokines.

1. Process samples.
2. CC Subfamily detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types - Blood, serum, plasma, cell culture supernatant, cell lysate, cell culture medium, tissue homogenate, urine, tumor, etc.