Determination of Melting Point of New 1,3,4-oxadiazole Bearing 2-flouro-4-methoxy Phenyl Moiety by Open Capillary Method (CAT#: STEM-PPA-0093-YJL)

Introduction

1,3,4-Oxadiazole is a versatile lead molecule for designing potential bioactive agents. The 1,3,4-oxadiazole derivatives have been found to exhibit diverse biological activities such as antimicrobial, anti-HIV, antitubercular, antimalarial, analgesic, anti-inflammatory, anticonvulsant, hypoglycemic and other biological properties such as genotoxic studies and lipid peroxidation inhibitor.
Used extensively in the symptomatic treatment of rheumatic fever, arthritis (rheumatoid, osteo and Jaundice arthritis), myocardial infarctions and management of primary dysmenorrheal. The major side effects in the use of aryl alkanoic acids is their gastric irritation, which is partly due to the corrosive nature of carboxylic acid group present in them. In order to reduce or mask the side effects of carboxylic moiety, different 2,5-disubstituted-1,3,4-oxadiazoles (4a–m) is synthesized via the condensation of 4-hydroxybenzohydrazide with various aromatic acids in presence of phosphorus oxychloride respectively in the hope of getting potent biodynamic agents and evaluate their antimicrobial activity.