IL-8 Detection (CAT#: STEM-MB-0277-WXH)

Name: IL-8 Detection
SKU: STEM-MB-0277-WXH
Rating: 5 (1 reviews)

Introduction

IL-8 is a multi-source cytokine that can be produced by monocytes, macrophages, neutrophils, fibroblasts, epithelial cells, T cells, chondrocytes, vascular endothelial cells, liver cells, etc. The main activity is to attract and activate neutrophils, further aggravate the local inflammatory response, and cause the patient's condition to worsen. Recent studies have shown that the increase in IL-8 concentration is often the pathological basis for tissue damage in certain inflammatory diseases, and it is usually the key link that leads to the development of certain diseases. The signal of IL-8 in tumor cells may increase the tumorigenicity, metastasis, invasiveness and viability of the cells. In addition, it can induce glomerular mesangial cells (GMC) to produce extracellular matrix components such as collagen fibers III, IV, and laminin.

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Principle Applications Procedure Notes

Principle

There are two types of IL-8 receptors, called IL-8RA and IL-8RB. IL-8A is mainly distributed in neutrophils, monocytes, T cells and melanoma cells, and has a high affinity for IL-8. , Specifically binds to IL-8. IL-8RB is a non-specific receptor. In addition to binding to IL-8R, it can also bind other CXC chemokines (GRO-α, GRO-β, GRO-γ) and neutrophil activating peptide 2, and IL- 8. GRO-α, GRO-β, GRO-γ binding has high affinity. Each chemokine binds to one or several receptors and quickly transfers to the target inflammatory cell, thereby generating an activated signal transduction pathway, which then leads to chemotaxis, proliferation, differentiation and survival of the cell.

Applications

IL-8 can promote the expression of adhesion molecules by neutrophils, induce degranulation of neutrophils, and release proteolytic enzymes such as elastase, myeloperoxidase, etc.
IL-8 can suppress appetite, which is related to loss of appetite in diseases.
IL-8 can induce multi-gene transcription in independent factors related to tumor progression such as vascular regeneration, cell cycle management, migration and invasion, and escape.