Investigation of Extracellular transport of NPs (nanoparticles) by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0748-WXH)

Introduction

The effective transport of NPs through extracellular barriers, such as mucus and interstitium, may be critically important in order to achieve the desired therapeutic and/or diagnostic goals.
Particle tracking can be an invaluable tool to probe the quantitative transport properties of engineered nanomaterials as they move through these complex barriers. Information gathered from particle-tracking experiments can feedback into the design process to improve NP p hysicochemical properties and reach design aims.

Add to Cart Please Inquire

Principle Applications Procedure Materials Notes Related Products

Principle

Nanoparticle tracking analysis (NTA) is a method for visualizing and analyzing particles in liquids that relates the rate of Brownian motion to particle size. The rate of movement is related only to the viscosity and temperature of the liquid; it is not influenced by particle density or refractive index. NTA allows the determination of a size distribution profile of small particles with a diameter of approximately 10-1000 nanometers (nm) in liquid suspension.

Applications

NTA has been used by commercial, academic, and government laboratories working with nanoparticle toxicology, drug delivery, exosomes, microvesicles, bacterial membrane vesicles, and other small biological particles, virology and vaccine production, ecotoxicology, protein aggregation, orthopedic implants, inks and pigments, and nanobubbles.

Procedure

1. Sample preparation
2. Nanoparticle Tracking Analysis
3. NTA Data Processing, Display, and Interpretation

Materials

• Nanoparticle Tracking Analysis (NTA) instrument
• NanoSight instrument
• Nanoparticle Analyzer

Other recommended products

Analysis of Protein-Protein Interactions by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0712-WXH)
Study of polymeric nanoparticle-macrophage interactions by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0720-WXH)
Total virus particle determination by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0709-WXH)
Analyzing the miRNA content of extracellular vesicles by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0721-WXH)
Analysis of micelles by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0730-WXH)
Characterization of Amyloid-β Self-Assembly by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0716-WXH)
Analysis of Copper nanoparticles by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0747-WXH)
Investigation of Nanoparticles (NP) intracellular transport by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0740-WXH)