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Micelles are lipid molecules that arrange themselves in a spherical form in aqueous solutions. The formation of a micelle is a response to the amphipathic nature of fatty acids, meaning that they contain both hydrophilic regions (polar head groups) as well as hydrophobic regions (the long hydrophobic chain).
Micelles have been widely used as drug delivery carriers for a series of different molecules, including low molecular mass hydrophobic drugs, proteins, and genes.
Compared with other drug delivery strategies, micelles have two unmatched advantages. The first is their relatively small size. The second advantage of micelles is their feasibility of large-scale manufacture. A micelle is the simplest assembled entity, with well-defined molecular structures and assembly behaviors.