MAPK Pathway Assay (CAT#: STEM-MB-0339-WXH)

MAPK is composed of extracellu larsignal regulated kinases (ERK MAPKs, Ras/Raf/MEK/ERK), C-Jun-N terminal kinases/stress activated protein kinases (thee-Jun Nterminal kinases/stress activated protein kinases, JNK MAPKs/SAPMAPKs3 and p38MAPK consist of three main sub-families. It is currently known that these cascades can change the expression of tumor-related genes. The ERKMAPK pathway is the most important signal transduction pathway for cell proliferation.
MAPK signal transduction pathway is an important signal system that mediates cellular responses. The MAPK cascade is very complex. These pathways can be activated by different extracellular signals, and then specific extracellular stimulation signals induce protein kinase tyrosine phosphate. The conversion is converted to protein kinase serine/threonine phosphorylation, which allows the signal to be transduced downstream. Therefore it is located at the convergence point of many cytokine signal transduction pathways.

To study the regulation mechanism of MAPK cell signal pathway in disease
To study the effect of each virus on MAPK cell signaling pathway
To study the effects of drugs or therapies on MAPK cell signaling pathways

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Detectable targets: A-Raf, B-Raf, c-Raf, MLK3, TAK, DLK, MEKK1, MEKK4, ASK1, MEKK2, MEKK3, TPI2, MEK1, MEK2, MKK3, MKK6, MKK4, MKK7, MEK5, ERK1, ERK2, p38, JNK1, JNK3, JNK2, ERK5, BMK1, SAPK, MKP1, MKP2, MKP3, MKP4, hVH5, MAPK