GM-CSF Detection (CAT#: STEM-MB-0264-WXH)

GM-CSF is a polypeptide factor with a broad spectrum of effects, which has a proliferative effect on early hematopoietic progenitor cells. GM-CSF receptor(GM R) is a transmembrane glycoprotein, a member of the cytokine receptor superfamily. It consists of two subunits: α (GM Rα) and β (GM Rβ). They can be divided into extramembrane region, transmembrane region and cytoplasmic region. Among them, the α-subunit has ligand specificity, and can specifically bind to GM-CSF with a low affinity, but cannot transmit signals. Although the β subunit itself cannot bind to GM-CSF, it can form a receptor complex that binds to the ligand with high affinity with the α subunit and transmits the stimulation signal stimulated by the ligand, causing various biological behaviors of the cell. Because neither the α nor β subunits have tyrosine kinase domains, after the α subunits bind to the ligand, they must form a heterodimer with the β subunits through spatial allometry before they can stimulate the cells. Matrix tyrosine kinase is phosphorylated to transmit signals, so receptor dimerization is key to signal transduction.

GM-CSF mainly stimulates the growth and differentiation of bone marrow precursor cells.
GM-CSF has the function of lowering serum cholesterol, which can be used to treat myeloid cell proliferation syndrome.
GM-CSF plays a key role in the development and maturation of dendritic cells and the proliferation and activation of T cells, linking innate and adaptive immune responses.
GM-CSF is used to improve neutropenia in elderly patients with acute myeloid leukemia after induction chemotherapy.

1. Process samples.
2. GM-CSF detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types- Serum, plasma, etc.