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Angiogenesis is defined as the physiological process of forming new blood vessels from pre-existing blood vessels. It is a key process that promotes development, skeletal muscle hypertrophy, menstruation, pregnancy, and wound healing, but can also cause pathological conditions, including neovascular diseases (such as retinopathy), rheumatoid arthritis, psoriasis, AIDS/Kab West Sarcoma and Cancer. Angiogenesis is a complex and highly ordered process that relies on endothelial cells (EC), their associated parietal cells (vascular smooth muscle cells [VSMC] and pericytes) and other cell types (such as immune cells) between and within Extensive signal network.