Methylated RNA Immunoprecipitation sequencing (MeRIP-Seq) (CAT#: STEM-MB-0068-WXH)

Introduction

RNA methylation refers to the methylation modification that occurs at different positions on the RNA molecule. Common post-transcriptional modifications of RNA include N6-methyladenosine(m6A) and C5- methylcytidine(m5C).
Studies have found that m6A modification plays an important role in regulating gene expression, splicing, RNA editing, RNA stability, controlling mRNA lifespan and degradation, and mediating circular RNA translation. Methylated RNA Immunoprecipitation with Next Generation Sequencing (MeRIP-Seq) is the latest technology to study the epigenetic modification of transcriptome in cells. This technology uses N6-methyladenine antibody to enrich highly methylated RNA fragments, and then combines high-throughput sequencing to study methylated RNA regions in the whole transcriptome, thereby comparing different cells, tissues, and samples. Differences in the RNA methylation modification patterns between different groups can help solve biological problems such as cell differentiation, biological development, disease occurrence and development, and heat shock response.