PLK Signaling Pathway Assay (CAT#: STEM-MB-0315-WXH)

Introduction

Polo-like kinase (PLK) is a highly conserved serine/threonine protein kinase with a highly homologous serine/threonine kinase domain at its N-terminus, which regulates PLK activity and subcellular dynamics at the C-terminus and targeted polo-box domain (PBD). There are many PLK family members, and there are four subtypes in the human body, namely PLK1, PLK2, PLK3, and PLK4, which play important roles in the regulation of various phases of the cell cycle. Among the four family members, the current research on PLK1 is the most thorough. PLK proteins regulate many key steps in the cell cycle, including the formation of bipolar spindles, chromosome segregation, late regulation of complexes, and cytokinesis. PLK is a very effective anticancer strategy as a target for inhibiting spindle formation during mitosis, thereby preventing cancer cell division.