Analysis of ICAM-3 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0262-LGZ)

Introduction

Intercellular adhesion molecule 3 (ICAM-3), also known as CD50, is a member of the immunoglobulin superfamily that binds to leukocyte integrins LFA-1 (CD11a/CD18) and αd/β2. ICAM-3 is expressed on leukocytes and epidermal Langerhans cells. ICAM-3 is a transmembrane glycoprotein expressed by leukocytes and is a counter-receptor for lymphocyte function-associated antigen (LFA)-1 integrin. In addition to acting as an adhesion molecule for T cells to contact antigen-presenting cells, ICAM-3 also regulates the affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an important role in the initiation of immune responses by T cells and antigen-presenting cells.