Analysis of TREM-2 by ELISA (CAT#: STEM-MB-1571-LGZ)

Introduction

Myeloid trigger receptor 2 (TREM2) is a single Ig domain receptor that is expressed in macrophages and dendritic cells, but not in granulocytes or monocytes. It is most plentifully expressed in the basal ganglia, corpus callosum, bulbar and spinal cord, while microglia cells in the central nervous system are the most dominant cell type producing TREM2. TREM2 plays a role in chronic inflammation by stimulating the production of chemokines and cytokines that are constitutive, but not inflammatory. TREM2 forms receptor signaling complexes with TYROBP to activate immune responses in macrophages and dendritic cells. It is also associated with the adaptor protein DAP12 to transmit activation signals that play a role in innate and adaptive immune responses. TREM2 signaling is also an important pathway that promotes colon wound healing.