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Turbidimetric immunoassay, also known as immunoturbidimetry or turbidimetry, is based on measuring the turbidity of a sample to determine the level of an analyte. This method is commonly used to quantify antigen-antibody complexes. This assay has been widely used in clinical diagnosis, e.g., measurement of PAI-1 and serum C-reactive protein (CRP).
Latex-enhanced immunoturbidimetry (LETIA) is an optimization for conventional immunoturbidimetry. In LETIA, inert microscopic particles amplify the immune complexes, significantly increasing the sensitivity of the reaction and detection.