HGF Signaling Pathway Assay (CAT#: STEM-MB-0372-WXH)

HGF an endogenous tissue repair factor, attenuates apoptosis in many primitive cell types. the HGF signaling pathway eliminates Ang II-induced apoptosis by inhibiting cytochrome c release, caspase-3 activation, and DNA fragmentation. RNA immunoprecipitation experiments show that HGF stabilizes Bcl-xL mRNA by increasing nucleotide binding to the 3' untranslated region of Bcl-xL mRNA, which is associated with the cytoplasmic localization of nucleotides. hGF also blocked Ang II-induced caspase-3 activation and lactate dehydrogenase release in tissue explants in an ERK-dependent manner.

Study the impact of each clinical virus on the HGF signaling pathway
Research on the regulatory mechanism of HGF signaling pathway in medicine

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Detectable targets: RTK, PI3K, TYK2, STAT1, STAT2, STAT3, PSGL1, TLR3, MAPK, TRAF5, MHC-II, RIP1, IRS2, TLR4, IRF3, PKR, icam1, Mda-5, MSK1, Rac1, CREB, mTOR, IRS1, MEKK1, Tak1, MYD88, TRAF6, ISRE, MEK6, IRF9, TRIF, JNK, SH2, Fas, p50, GAS, TNFR, IRAK4, p38MAPK, p38, SLP76, TRAF3, ISGF3, STAT5, MEK3, TLR9, TRAM, RIG-1, MSK2, Vav, IRF5, Rel, TCR, NFκB, PI3K, TBK1, CD3, NAP1