IFN-γ Detection (CAT#: STEM-MB-0269-WXH)

Introduction

According to the different primary structure of interferon protein, it is divided into three types of α, β and γ. Interferon gamma (IFN-γ) is produced by immune lymphocytes. The gene structure contains introns and plays an important role in the adaptive immune response. IFN-γ is a multipotent cytokine that can promote macrophage activation, mediate antiviral and antibacterial immune responses, enhance antigen presentation, activate the innate immune system, coordinate the interaction of lymphocytes and endothelial cells, regulate the balance between Th1 and Th2 cells and regulate cell proliferation and apoptosis. In the adaptive immune response, IFN-γ is produced by CD4+ helper T cells (Th1) and CD8+ cytotoxic T cells (CTL) when stimulated by antigens presented by the major histocompatibility complex (MHC). In the innate immune response, IFN-γ is produced when natural killer cells (NK cells) are stimulated by interleukin 12 (IL-12) and interleukin 18 (IL-18).